OC10.05: *Increased nuchal translucency in congenital heart defects: associations with mortality

The objective was to investigate if increased NT associated with mortality in children CHD. In a nationwide cohort using population-based registries, 5,633 liveborn Denmark pre or postnatal diagnosis of CHD from 2008-2018 (0.7%) were identified. Children lack data on first trimester screening, chromosomal abnormalities no match between registries excluded. Increased defined as > 3.5 mm 1.5 Multiples Median (MoM). Proportions compared chi-squared test significance level 0.05. Of 4,469 eventually included the cohort, 754 (17%) had complex and 3,715 (83%) simple these, 239 (5.3%) an >1.5 MoM, 57 (1.3%) >3.5 mm. Mortality higher MoM than <1.5 (3.3% vs. 1.5%, p = 0.03). for when (2.3% vs 0.6%, 0.01). Amongst undergoing surgery significantly found group (8.6% 2.5%, 0.04). Complex more frequent (27% 16%, < 0.01), but not (6.1% 5.8%, 0.93) there difference (4.3% 7.5%, 0.44). Due limited numbers association could be assessed. Confounding birth variables: gestational age, birthweight, small preterm birth, pre-eclampsia, placental weight, maternal smoking, BMI, beta-HcG, PAPP-A equally distributed MoM. born CHD, mortality. primarily evident infants possibly independent predictor